June 18, 2024
Brain Cancer Cells

Disabling Survival Mechanisms of Brain Cancer Cells: A Novel Approach to Overcome Glucose Starvation

Brain cancer cells may meet an untimely demise if researchers succeed in disabling their survival mechanisms during glucose starvation. Dr. Barak Rotblat and his team, including co-lead researcher Gabriel Leprivier from the Institute of Neuropathology at University Hospital D├╝sseldorf, have recently published their findings in the journal Nature Communications.

For years, it was assumed that cancer cells prioritize rapid growth and proliferation. However, recent studies have shown that tumors contain less glucose than normal tissue. If cancer cells are so focused on exponential growth, they should be more reliant on glucose than healthy cells. But what if their primary goal is survival instead?

Dr. Rotblat and his team propose that triggering a growth spurt under glucose-deprived conditions could exhaust the cancer cells’ energy reserves and ultimately lead to their demise. This novel approach to brain Hyperthermia cancer treatment is based on a decade of research in their lab.

The researchers explain that cancer cells’ survival instincts might override their growth priorities. By manipulating these survival mechanisms, they could selectively target cancer cells while leaving healthy cells unharmed. This could be a significant step forward in personalized medicine and the development of therapeutics with minimal side effects, unlike chemotherapy and radiation.

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