by The Single-Use Bioreactor Market is estimated to be valued at US$ 1337.67 Mn in 2023 and is expected to exhibit a CAGR of 15 % over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.
Market Overview:
Single-use bioreactors are disposable bioreactors used for culturing microorganisms or cell cultures in bioprocesses such as downstream processing, cell culture development, and scale-up for higher yields. Their advantages over stainless steel bioreactors include lower capital costs, easier scale-up, less contamination risk, and less downtime between production runs. The products are available in ranges of working volumes from 10 liters to 2,000 liters. Typical uses involve fast clinical trials of new biologics and production of vaccines.
Market Dynamics:
Single-use bioreactors are witnessing high demand due to increasing adoption of disposable technologies in biopharmaceutical manufacturing. Their use reduces project costs, production timelines, and environmental footprint. However, relatively high material costs remain a challenge. Nonetheless, growing biologics production for diseases such as cancer and COVID-19 is driving substantial new capacity additions, benefiting the single-use bioreactor market. Product innovations involving 3D cell culture models and perfusion technologies have also expanded application scope in areas like stem cell therapy and tissue engineering.
Segment Analysis
The single-use bioreactor market is dominated by the 5L to 50L sub segment. This sub segment holds around 35% of the market share owing to increasing demand for single-use bioreactors in the range of 5L to 50L from small to medium sized biopharmaceutical companies working on discovery, research and development stages. The 5L to 50L bioreactor capacity is suitable for handling small to medium batch production volumes in R&D as well as pre-clinical and phase I/II clinical manufacturing.
PEST Analysis
Political: The regulatory agencies like US FDA encourage adoption of single-use bioreactors as it eliminates the need for validation and cleaning of traditional stainless steel-based bioreactors thus reducing compliance requirement.
Economic: Significant cost benefits of single-use bioreactors over stainless steel bioreactors has spurred their adoption. The manufacturing and operation costs are reduced as no cleaning and sterilization is required.
Social: Increasing demand for biologics has prompted biopharmaceutical companies to scale-up drug substance manufacturing capabilities. Single-use bioreactors allow quick scale-up thus meeting the social need for biologics in a timely manner.
Technological: Advancements in single-use material formulations, sensors and control systems have enhanced the functionality of single-use bioreactors. Technologies like pre-sterilized connectors, self-validating bags further augment their usage.
Key Takeaways
The global Single-Use Bioreactor Market Share is expected to witness high growth, exhibiting 15% CAGR over the forecast period of 2023 to 2030, due to increasing demand for flexible and easy-to-use bioprocessing solutions from biopharmaceutical companies. The market size for 2023 is estimated to be US$ 1337.67 Mn.
Regionally, North America dominates the single-use bioreactor market and is expected to continue its dominance during the forecast period. This is attributed to presence of large number of major biopharmaceutical companies and favorable regulatory environment supporting adoption of single-use solutions in the region. Asia Pacific is anticipated to witness fastest growth owing to rising biosimilars production, increasing R&D investments for biologics development and supportive government policies encouraging domestic pharmaceutical manufacturing.
Key players operating in the single-use bioreactor market include Sartorius AG, OmniBRx Biotechnologies, Merck KGaA, Solaris Biotechnology Srl, Eppendorf AG, Distek Inc., Celltainer Biotech BV, ABEC Inc., Thermo Fisher Scientific, and Danaher Corporation (Pall Corporation), among others. The players cater to varied industry needs by providing array of single-use bioreactor products with different working volumes and technologies. For instance, Sartorius offers single-use bioreactors with capacities ranging from 5L to 3000L. Meanwhile, Thermo Fisher Scientific provides single-use bioreactors integrated with advanced sensors and control systems.
*Note:
1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
