June 18, 2024
Macrophages

Uncovering the Memory of Heart Failure: New Study Reveals Link Between Stress and Recurrent Heart Issues

Heart failure, a debilitating condition that affects millions worldwide, may leave a lasting impact on the body, according to recent research. The study, conducted by Japanese researchers, sheds light on the potential causes of recurrent heart failure and the deterioration of other organs.

Heart failure is known to induce stress on the body. This stress is not forgotten; instead, it leaves a mark in the form of modifications to the DNA of hematopoietic stem cells. These cells are responsible for producing blood and immune cells, including Macrophages, which play a crucial role in maintaining heart health.

However, during heart failure, a critical signaling pathway, TGF-β, in the hematopoietic stem cells is suppressed. This suppression negatively affects the production of macrophages, leaving the heart vulnerable to further damage.

The researchers believe that restoring TGF-β levels could be a promising approach to prevent recurrent heart failure. Furthermore, detecting the accumulation of stress memory could serve as an early warning system, allowing for timely intervention.

Heart disease remains the leading cause of death globally, with an estimated 26 million people living with heart failure. The United Nations’ Sustainable Development Goals emphasize healthier lives and improved well-being. While progress has been made in preventing diseases and improving survival rates, heart disease continues to pose a significant challenge.

The recurrence of heart failure and related health issues, such as kidney and muscle problems, can significantly impact a person’s quality of life. This study offers new insights into the underlying mechanisms of heart failure and opens up potential avenues for prevention and treatment.

*Note:
1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it.