by New research utilizing organoids, which are three-dimensional cell cultures that mimic the structure and function of the human intestine, has shed light on the intricate relationship between gluten consumption and intestinal damage in celiac disease.
According to recent findings published in the journal “Cell,” a team of researchers from the University of California, San Francisco (UCSF) discovered that gluten triggers a specific immune response in organoids derived from celiac disease patients. This response, in turn, leads to the production of a protein called Interleukin-15 (IL-15), which is known to contribute to intestinal inflammation and damage.
The UCSF team, led by Dr. Daniel Karpenstein, created organoids from intestinal stem cells taken from both celiac disease patients and healthy individuals. They then exposed these organoids to gluten and monitored their reactions. The results showed that the organoids derived from celiac disease patients produced significantly higher levels of IL-15 in response to gluten exposure, compared to the organoids from healthy individuals.
These findings provide crucial insights into the mechanisms behind celiac disease and the role of gluten in intestinal damage. The researchers believe that their discovery could lead to the development of new therapeutic approaches for treating celiac disease, such as drugs that target the IL-15 pathway.
Dr. Karpenstein stated, “Our study provides a unique opportunity to study the disease in a more physiologically relevant system than traditional two-dimensional cell cultures. We hope that this new understanding of the disease will help us develop better treatments for celiac disease.”
In summary, this groundbreaking research using organoids has uncovered a new link between gluten consumption and intestinal damage in celiac disease, offering potential avenues for the development of novel therapeutic strategies.
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1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
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