by A groundbreaking study led by the Molecular and Cellular Neurobiotechnology team at the Institute for Bioengineering of Catalonia (IBEC) and the University of Barcelona has identified a novel microRNA biomarker for Alzheimer’s disease in its asymptomatic stages. The discovered microRNA is miR-519a-3p, which is directly associated with the expression of the cellular prion protein (PrPC). Deregulation of PrPC is a common characteristic of neurodegenerative diseases, including Alzheimer’s.
The researchers published their findings in the prestigious journal Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. This discovery holds significant promise for the early detection of Alzheimer’s disease, as stable and easily detectable biomarkers like microRNAs could potentially enable diagnosis in the asymptomatic stages. Early detection is crucial for improving the diagnosis and treatment of Alzheimer’s, which currently affects over 35 million individuals worldwide.
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